A Leukemic B-cell Lymphoma with Special Reference to Cytogenetic and Immunologic Markers

Abstract

A 65-year-old female was admitted to our hospital because of persistent high fever, and remarkable hepatosplenomegaly. On admission abnormal cells (14%) were found in the peripheral blood. The diagnosis of leukemic B-cell leymphoma was made according to the hematological and immunological marker studies. Cytogenetic study was also revealed a pseudodiploid chromosome costitution with the presence of three consistent marker chromosomes, t(1;14)(p13;q22), t(1;9;16)(q21;q13;p13) and a medium-sized unidentifiable one. With DMA/DAPI staining, the latter was shown to have an extremely large and brightly fluorescent region which might be coincidental with the heterochromatic HSR described by Barker et al (1979).