Abstract
A 38-year-old woman with complaints of hematuria, lower abdominal pain and high fever was diagnosed as thrombotic thrombocytopenic purpure (TTP) by typical clinical findings including severe hemolytic anemia, thrombocytopenia, moderate proteinuria and paroxysmal convulsions accompanied with hemiparesis. She progressively became comatic with apnea within a week, inspite of the treatment with oral administration of 8 mg dexamethasone daily in addition to transfusions of fresh blood and platelet-rich plasma. Then, the therapy was changed to intravenous administration of 15 mg dexamethasone, 110 mg dipyridamole and 60,000 units of urokinase daily, while under controlled respiration using a respirator. She recovered spontaneous breathing and clear consciousness within ten days without any residual defects. After remission, She was well controlled by daily combined medications of 1.0 g Aspirin and 150 mg dipyridamole with prednisolone, which was gradually decreased and discontinued by the day of her discharge.
A brief discussion was added referring to other documents and reports.
