Childhood Acute Myeloblastic Leukemia with t(8q-; 21q+)

—A Report of 6 Cases and a Review of the Literature—

Abstract

Six cases of childhood acute myeloblastic leukemia (AML) with t(8q-; 21q+), three boys and three girls aged from 4 to 14, are reported. Of these, three cases had t(8q-; 21q+) plus a missing sex chromosome. Five cases achieved complete remission. Twenty-nine cases of childhood AML with t(8q-; 21q+), including our cases, were reviewed from the literature. Seventy-one percent of the cases reviewed had a missing sex chromosome, and seventy-nine percent obtained complete remission. The overall survival rate was 66% at one year, and 25% at 2 years.
Thus, childhood AML with t(8q-; 21q+) seemed to have a better prognosis than that without t(8q-; 21q+).