1983 Volume 24 Issue 4 Pages 433-439
The effect of certain disease parameters on response rate and survival time was evaluated in 47 patients with multiple myeloma treated with MIP therapy.
The results as follow:
1) In the response rate, older than 70 years old, female and poor risk factors such as anemia, hypercalcemia and hypoalbuminemia were associated with high response rates. IgA myeloma also showed higher response rate, in comparison with IgG myeloma.
2) In the survival time, older than 70 years old, male and poor risk factors such as hypoalbuminemia, elevated M-protein, hypercalcemia and extensive boone lesion were associated with short survival times. In addition, advanced stage showed significantly short survival times.
3) Greater degrees of M-protein reduction from chemotherapy were associated with longer survival times. Patiens in whom a marked M-protein reduction was rapid had longer remission and survival times than patients more slowly.
4) In the types of morphological myeloma proliferation, high respons rate on tumor forming type and long survival time on diffus proliferative type were obviously observed.
