Abstract
In patients with leukemia and aplastic anemia who received allogeneic bone marrow transplantation, the association between titer of antibodies in serum to cytomegalovirus (CMV) and herpes simplex virus (HSV) using complement fixation (CF) method and their infections was analysed.
(1) All seven patients examined had CMV infections following transplantation and they had negative or very low CF titer to CMV prior to marrow graft.
(2) Three patients who had the titer more than 1: 512 after marrow transplantation recovered from CMV infections.
(3) A large number of granulocyte transfusions from random donors were performed in all patients. The association of granulocyte transfusions with CMV infections was strongly suspected.
(4) 321 persons of 371 healthy donors (62.3%) had negative CF antibodies to CMV. It was considered that seronegative donors should have priority as potential donors of granulocyte transfusions.
(5) Four seronegative patients for HSV prior to marrow graft did not develop HSV infection. Five out of seven seropositive patients before transplantation, however, were suffered from HSV infection following marrow graft.
(6) Whenever patients had more than 1: 128 titers to HSV, no symptome of HSV infection appeared.
