多発性骨髄腫における多剤併用療法(Modified M-2 Protocol)の治療成績

岩田 吉史; 仮谷 嘉晃; 田中 公; 小林 透; 大野 敏之; 影山 慎一; 片山 直之; 片岡 吉貴; 神尾 典彦; 太田 千鶴子; 康 龍男; 宇野 伸郎; 浜口 均; 南 信行; 白川 茂

doi:10.11406/rinketsu.25.1380

Combination Chemotherapy (Modified M-2 Protocol) for Multiple Myeloma

Yoshifumi IWATA, Yoshiaki KARITANI, Isao TANAKA, Tohru KOBAYASHI, Toshiyuki OHNO, Shinichi KAGEYAMA, Naoyuki KATAYAMA, Yoshitaka KATAOKA, Norihiko KAMIO, Chizuko OHOTA, Tatsuo KOH, Nobuo UNO, Hitoshi HAMAGUCHI, Nobuyuki MINAMI, Shigeru SHIRAKAWA

Author information

Yoshifumi IWATA
The Second Department of Internal Medicine, Mie University of Medical School
Yoshiaki KARITANI
The Second Department of Internal Medicine, Mie University of Medical School
Isao TANAKA
The Second Department of Internal Medicine, Mie University of Medical School
Tohru KOBAYASHI
The Second Department of Internal Medicine, Mie University of Medical School
Toshiyuki OHNO
The Second Department of Internal Medicine, Mie University of Medical School
Shinichi KAGEYAMA
The Second Department of Internal Medicine, Mie University of Medical School
Naoyuki KATAYAMA
The Second Department of Internal Medicine, Mie University of Medical School
Yoshitaka KATAOKA
The Second Department of Internal Medicine, Mie University of Medical School
Norihiko KAMIO
The Second Department of Internal Medicine, Mie University of Medical School
Chizuko OHOTA
The Second Department of Internal Medicine, Mie University of Medical School
Tatsuo KOH
The Second Department of Internal Medicine, Mie University of Medical School
Nobuo UNO
The Second Department of Internal Medicine, Mie University of Medical School
Hitoshi HAMAGUCHI
The Second Department of Internal Medicine, Mie University of Medical School
Nobuyuki MINAMI
The Second Department of Internal Medicine, Mie University of Medical School
Shigeru SHIRAKAWA
The Second Department of Internal Medicine, Mie University of Medical School

Keywords: multiple myeloma, combination chemotherapy

JOURNAL RESTRICTED ACCESS

1984 Volume 25 Issue 9 Pages 1380-1387

DOI https://doi.org/10.11406/rinketsu.25.1380

Details

Abstract

Twenty patients with multiple myeloma were treated with a combination chemotherapy, consisting of melphalane, cyclophosphamide, ACNU, vincristine, and prednisolone (modified M-2 protocol). Twelve of 20 patients had no prior treatment, while 8 of 20 had been resistant to melphalane or cyclophosphamide.
A good response was obtained in 11 of 20 cases (55%), and a limited response in 5 of 20 cases (25%). The response rate was 80% in total cases. The response rate in the patients with high tumor mass (Stage III) was higher than that with low tumor mass (Stage I, II).
Modified M-2 protocol appered to be effective not only as induction therapy for high tumor mass patients, but also for such patients as resistant to melphalane-prednisolone.

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