急性白血病におけるCytosine Arabinoside大量療法：多施設共同研究

浦部 晶夫; 高久 史麿; 溝口 秀昭; 山田 修; 若林 芳久; 三浦 恭定; 坂本 忍; 吉田 稔; 三輪 史朗; 浅野 茂隆; 森崎 隆幸; 野村 武夫; 外山 圭助; 青木 功; 村瀬 忠; 前川 正; 宮脇 修一; 村上 博和; 山田 英雄; 大野 竜三; 川島 康平; 横幕 省三; 衣笠 恵士; 足立 山夫; 森 眞由美; 伊勢 泰; 武藤 良知; 山口 潜

doi:10.11406/rinketsu.26.184

High-Dose Cytosine Arabinoside in Acute Leukemia: A Cooperative Study

Akio URABE, Fumimaro TAKAKU, Hideaki MIZOGUCHI, Osamu YAMADA, Yoshihisa WAKABAYASHI, Yasusada MIURA, Shinobu SAKAMOTO, Minoru YOSHIDA, Shiro MIWA, Shigetaka ASANO, Takayuki MORISAKI, Takeo NOMURA, Keisuke TOYAMA, Isao AOKI, Tadashi MURASE, Tadashi MAEKAWA, Shuichi MIYAWAKI, Hirokazu MURAKAMI, Hideo YAMADA, Ryuzo OHNO, Kohei KAWASHIMA, Shozo YOKOMAKU, Keiji KINUGASA, Yamao ADACHI, Mayumi MORI, Tohru ISE, Yoshitomo MUTOH, Hisomu YAMAGUCHI

Author information

Akio URABE
The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Fumimaro TAKAKU
The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Hideaki MIZOGUCHI
The First Department of Internal Medicine, Tokyo Women's Medical College
Osamu YAMADA
The First Department of Internal Medicine, Tokyo Women's Medical College
Yoshihisa WAKABAYASHI
Department of Medicine, Juntendo University School of Medicine
Yasusada MIURA
Department of Hematology, Jichi Medical School
Shinobu SAKAMOTO
Department of Hematology, Jichi Medical School
Minoru YOSHIDA
Department of Hematology, Jichi Medical School
Shiro MIWA
Department of Medicine, Institute of Medical Science, University of Tokyo
Shigetaka ASANO
Department of Medicine, Institute of Medical Science, University of Tokyo
Takayuki MORISAKI
Department of Medicine, Institute of Medical Science, University of Tokyo
Takeo NOMURA
The Third Department of Internal Medicine, Nippon Medical School
Keisuke TOYAMA
Department of Medicine, Keio University School of Medicine
Isao AOKI
Department of Medicine, Keio University School of Medicine
Tadashi MURASE
Department of Medicine, Keio University School of Medicine
Tadashi MAEKAWA
The Third Department of Internal Medicine, Gunma University School of Medicine
Shuichi MIYAWAKI
The Third Department of Internal Medicine, Gunma University School of Medicine
Hirokazu MURAKAMI
The Third Department of Internal Medicine, Gunma University School of Medicine
Hideo YAMADA
The First Department of Internal Medicine, Nagoya University School of Medicine
Ryuzo OHNO
The First Department of Internal Medicine, Nagoya University School of Medicine
Kohei KAWASHIMA
The First Department of Internal Medicine, Nagoya University School of Medicine
Shozo YOKOMAKU
The First Department of Internal Medicine, Nagoya University School of Medicine
Keiji KINUGASA
Department of Medicine, Bokuto Hospital
Yamao ADACHI
Department of Medicine, Bokuto Hospital
Mayumi MORI
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
Tohru ISE
Department of Pediatrics, National Cancer Center Hospital
Yoshitomo MUTOH
Department of Hematology, Toranomon Hospital
Hisomu YAMAGUCHI
Department of Hematology, Toranomon Hospital

Keywords: high-dose Ara-C, acute leukemia

JOURNAL RESTRICTED ACCESS

1985 Volume 26 Issue 2 Pages 184-188

DOI https://doi.org/10.11406/rinketsu.26.184

Details

Abstract

High-dose cytosine arabinoside (3g/m² as a 120-min infusion every 12 hours for 6 days) was administered to 30 patients with relapsed refractory acute leukemia with the following results: 12 patients (40%) achieved complete remission, and 5 patients achieved partial remission. The median duration of complete remission was more than 4 months. The toxicity was tolerable, and remission could be achieved even in patients who had failed to respond to cytosine arabinoside in conventional doses.

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