Abstract
A case of a 41-year-old man with systemic lymphadenopathy was evaluated from cytochemical findings of leukemic cells and clinical responses for anti-leukemic agents. At first, diagnosis of acute myeloblastic leukemia was made based upon the routine morphological examination of the peripheral blood and the bone marrow specimen. In further examination, the myeloid feature was demonstrated in the leukemic cells of the bone marrow, in contrast to the lymphoid feature in those of the lymph node, supporting the diagnosis of mixed leukemia. Furthermore, cytogenetic study showed almost same karyotypic abnormalities including a ring chromosome, which suggested the leukemic transformation on the near level of pluripotent stem cell.
