Relationship Between Prognosis and CFU-C-derived Colony Formation in Patients with Aplastic Anemia

Abstract

We studied on the prognosis and in vitro CFU-C-derived colony formation of 19 patients with aplastic anemia. In the assay of CFU-C, the patients with severe aplastic anemia had very low colonies and clusters. Anabolic steroids were effective on 57% of patients, and were less effective on patients with severe disease than on patients with mild disease. There was no difference between oxymetholone and mepitiostane on the effect or the adverse effect. Anabolic steroids were more effective on patients having higher CFU-C colony formation. Immunosuppressive therapy was effective on a part of patients, whose CFU-C increased early after the therapy.