Abstract
We reported a case of 34 yrs old man. He was admitted to our hospital with complains of anemia and splenomegaly.
Laboratory findings were as follows: Hb13.1 g/dl Plts 10.5×104/μl, WBC 5,900/μl (tumor cell 2.5%), LDH 1,200 WU, Lysozyme 13.4 μg/ml, IgG 919 mg/dl, IgM 543 mg/dl. Bone marrow finding showed normocellular with 18.2 tumor cells. Cytogenetic study revealed ahypertetraploid type. This case was diagnosed as malignant histiocytosis from morphologic features, cytochemical studies of tumor cells, and clinical course.
After four months from admission, the serum a marked elevation of monoclonal IgM of Kappa type. The tumor cells were strained with IgM florescence antibody technique and might produce immunoglobulin was suggested. The chemotherapy combined with cyclophosphamide, vincristine, ACNU, and prednisolone, and radiation therapy to splenomegaly were ineffective. He died with plumonary bleeding in October 1980. The total survival of this patient was about one year.
Pathological findings were as follows: Systemic enlargement of the lymphnodes and diffuse infiltration of tumor cells into kidney, liver, and spleen.
We discussed the correlation of macrogloblinemia and cytogenetic study in malignant histocytosis.
