A Case Report of Acute Myelogeneous Leukemia Transplanted from Three-Year-Old Sister and Managed in Bed Isolator

Abstract

A six-year-old boy with acute myelogenous leukemia (AML) in first remission received a bone-marrow transplant from his three-year-old HLA-identical sister after preparation with cyclophosphamide and fractionated total-body irradiation. Engraftment was documented by chromosomal analysis on day 14. The patient was placed in a laminar-air-flow bed isolator and no febrile episode was noted during isolation. 100 days after transplantation the patient has no graft-versus-host disease, no infections, and no other complications. Since cytomegalovirus pneumonia after this period, and recurrence of AML is unusual, the probability of long term survival in this patient is high.