1986 Volume 27 Issue 10 Pages 1850-1855
Chromosomal analysis on T cell malignancies including 10 cases of adult T cell leukemia and 6 cases of nonendemic T cell malignant lymphoma was performed comparing with 25 cases of non T cell malignancies.
The structural rearrangements in T cell malignancies were most commonly found in No. 7 (63%) and NO. 12 (50%) in contrast with 28% and 16% respectively in non T cell malignancies. No consistent break point in No. 7 was found, but the translocation at band q24 in N. 12 was highly characteristic with a frequency of 63% (5/8).
This abnormality in No. 12 could be related to the oncogene, k-ras-2, which is known to be located on the No. 12. Therefore 12q24 thought to be a clonal marker in T cell malignancies as 14q32 in non T cell malignancies.
