Abstract
Two cases of aplastic anemia transforming to myelodysplastic syndromes via hematological remission were reported. Case 1, a 47 year-old housewife was diagnosed severe aplastic anemia at 41 years of her age. Complete remission was attained following androgen therapy 3 years after diagnosis. Two years later anemia reappeared with monocytosis. Her bone marrow showed hyperplasia with prominent dyshematopoiesis. The anemia was refractory to androgen anymore. Case 2, a 28 year-old female previously diagnosed as moderate aplastic anemia and being in remission after androgen therapy for 4 years was admitted to our hospital because of anemia and bleeding tendency. Laboratory data showed high LDH level and ineffective erythropoiesis.
We also reviewd 21 cases in the literature transforming from aplastic anemia to myelodysplasia through remission similar to our cases and proposed a concept of aplastic anemia-myelodysplasia syndrome.
