A Case of Sweet's Syndrome Associated with Acute Myeloblastic Leukemia

Abstract

The patient was a 21-year-old female who had been diagnosed as acute myeloblastic leukemia in 1979. Complete remission was achieved, but she relapsed in May 1985, and was treated with daunorubicin and cytosine arabinoside. On day 12 of therapy, tender, edematous red plaque was appeared on the anterior chest, and on next day similar lesions involved the trunk, lip, anticubital fossa accompanied by fever. Histological examination of skin biopsy showed a marked infiltration of neutrophils in the dermis. A diagnosis of Sweet's syndrome was made, and skin lesions were improved rapidly with prednisolone.
Recently, cases of Sweet's syndrome associated with internal malignancy, especially with leukemia, have been reported, and etiological relationships with these diseases are noted. We report our case of patient, and those reported in the literature.