Abstract
Hemostatic abnormalities of patients with various types of liver disease registered to the Japanese Research Committee on Coagulopathy including DIC were analysed. In patients with liver cirrhosis, apparent abnormalities were observed in various coagulation tests, which were scored 3 points per person on an average by a diagnostic criteia for DIC proposed by the Japanese Research committee on DIC. Since catabolism of both AT III and prothrombin labeled with radiolodine was not accelerated in these patients, decreased production of various clotting factors seemed to be a main cause of these abnormalities. In patients with acute or chronic hepatitis without severe hepatic dysfunctions, abnormality was minimal in various coagulation tests which were scored less than 1 point. On the basis of these findings, a modified diagnostic criteria for DIC have been proposed in fig 5.
