Multiple Liver Abscesses Successfully Treated by Intraportal Administration of Amphotericin B in a Case with AML (M2)

Abstract

A 39-year-old male was admitted in March, 1984 with diagnosis of AML (M2). Two courses of BH-AC·DMP regimen induced complete remission of short duration. Second hematologic remission was obtained with BH-AC·AMP regimen, while marked pyrexia did not resolve. CT scans revealed multiple poorly-defined low-density lesions in the swollen tender liver. Since the liver biopsy failed to yield any positive cultures, administration of amphotericin B was tried through a cathetelinserted into the portal vein at laparotomy, along with oral 5-fuluorocytosine because of suspected mycotic etiology. His fever resolved to normal in 2 weeks after institution of this therapy, and the abnormal findings in CT scans disappeared as well. Amphotericin B was discontinued at the total dose of 1,076 mg without recurrence of the similar lesions.