Bone Marrow Transplantation for Treatment of Monosomy 7

Abstract

A three year-old boy with monosomy 7 received, as primary treatment, ablative chemotherapy and total body irradiation followed by bone marrow transplantation (BMT) from his HLA identical sister. Twenty three days after BMT he developed grade II GVHD which was treated with oral predonisolon. Chromosome showed normal female karyotype and no monosomy 7 on day 28.
Although platelets count trended to be low, bone marrow showed full recovery and his performance status was 100%.
He developed interstitial pneumonia on day 80 and died of respiratory failure on day 90.
In light of the poor prognosis of monosomy 7, bone marrow transplantation may represent the treatment of choice for patients who have an appropriate donor.