Abstract
Twenty-eight years old woman, who had been healthy and had no history of abnormal bleeding, developed wide ecchymoses and intramuscular bleeding 3 months after herfirst delivery.
On admission, the VIII: C was less than 1% and the VIII: C inhibitor (3.8 Bethesda U.) was detected, which consisted of IgG heavy chain and lambda light chain. Furthermore, platelet adhesiveness measured with glass beads column was 1.8%, although vWf activity was 80% in RIPA, 220% in agglutination method and 240 second bleeding time, and vWf: Ag was 245% in Laurell method and showed normal pattern on the crossed immunoelectrophoresis.
The patient was treated with factor VIII concentrate, plasma exchange therapy and steroid therapy. The platelet adhesiveness was normalized soon after steroid therapy. The inhibitor could not be detected also in 6th month.
