OKT4, OKT8陽性を示し，インターフェロン投与により症状の改善をみた成人T細胞白血病の1例

繁田 正子; 小野寺 秀記; 菅野 辰生; 小林 裕; 小澤 勝; 丸尾 直幸; 吉川 敏一; 金綱 隆弘; 近藤 元治; 林 英夫

doi:10.11406/rinketsu.28.1783

A Case of Adult T-cell Leukemia with Dual Expressions of OKT4 and OKT8: Clinical Improvement by Alpha Interferon

Masako SHIGETA, Hideki ONODERA, Tatsuo SUGANO, Yutaka KOBAYASHI, Masaru OZAWA, Naoyuki MARUO, Toshikazu YOSHIKAWA, Takahiro KANATSUNA, Motoharu KONDO, Hideo HAYASHI

Author information

Masako SHIGETA
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Hideki ONODERA
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Tatsuo SUGANO
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Yutaka KOBAYASHI
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Masaru OZAWA
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Naoyuki MARUO
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Toshikazu YOSHIKAWA
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Takahiro KANATSUNA
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Motoharu KONDO
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Hideo HAYASHI
The Department of Internal Medicine, Kyoto 2nd Red Cross Hospital

Keywords: ATL, double markers (OKT4/OKT8), interferon

JOURNAL RESTRICTED ACCESS

1987 Volume 28 Issue 10 Pages 1783-1789

DOI https://doi.org/10.11406/rinketsu.28.1783

Details

Abstract

A 45-year-old male, who was born in Miyazaki prefecture, was admitted with epistaxis. Hematological examinations revealed as follows; hemoglobin 6.2 g/dl and platelets 14000/mm³ and leukocytes 10600/mm³ with 67% of leukemic cells with convoluted nuclei.
Lymphnode and bone marrow biopsies were compatible with diagnosis of adult T-cell Leukemia. Anti-Adult T-cell Leukemia Virus Antibodies were positive. In the examination of phenotype, however, the leukemic cells expressed OKT4 and OKT8 simultaneously. Though conventional chemotherapy was uneffective, treatment with alpha interferon improved the symptoms and laboratory data. From these results, interferon seems useful for the therapy of ATL in cases of unresponsiveness to the conventional chemotherapy.

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