Abstract
The long-term prognosis of 29 children with aplastic anemia was studied. Out of 29 cases, 24 were idopathic aplastic anemia and 5 were Fanconi's anemia. The prognosis of idiopathic type was fairly well predicted by the criteria proposed by Hotta, et al. The percentage of hematopoietic cells in bone marrow significantly well predicted the prognosis; patients with less than 20% hematopoietic cells in bone marrow had significantly worse prognosis.
The long-term prognosis of 14 patients who had survived more than 1 year was not satisfactory. Hepatic tumors developed in 3 cases. Hepatomegaly of unknown etiology associated with jaundice, diabetes mellitus, and cataract were also seen. One patient with Fanconi's anemia developed leukemia as well as hepatoma.
There were only 2 (8%) survivors without any complications. This suggests that the development of complications should be kept in mind when considering the indications of bone marrow transplantation.
