A Case of Aggressive Plasma Cell Myeloma with Multilobated Nuclei

Abstract

A rare case of aggressive plasma cell myeloma of a 54-year-old female is reported. The patient was admitted to our hospital because of high fever and left exophthalamos. Hematological and serological studies revealed multiple myeloma, IgA-k type. Morphologically, the myeloma cells were characterized by their multilobated nuclei with distinct nucleoli, which have been believed to be a morphologic marker for T-cell origin. Clinically, she once responded to intensive chemotherapy, but soon relapsed with intraperitoneal tumor. She died of gastrointestinal bleeding and pneumonia 5 months after the diagnosis. Autopsy findings revealed giant tumor in the retroperitoneum and it invaded to soft tissues.
This case seemed to be corresponded to “Aggressive plasma cell myeloma”.