1987 Volume 28 Issue 2 Pages 220-227
Clinical courses of 13 patients who survived more than 2 years after allogeneic bone marrow transplantation (BMT) were analyzed. Ten patients with acute leukemia were conditioned with cyclophosphamide (CY) and total body irradiation (TBI). Eight of them received marrow graft at the first complete remission stage, and the other 2 received it at the second remission stage. Three patients with severe aplastic anemia were conditioned with CY alone. All except one who was given cyclosporin-A (CsA) were given MTX for prophylaxis of GVHD. Acute GVHD developed in 9 patients, but only 2 patients had severe GVHD (grade II or higher). Chronic GVHD which involved chiefly skin, liver and oral mucosa, developed in 11 patients. Four patients had interstitial pneumonia (IP), but all recovered. Most of patients had viral and/or bacterial infections during one year after BMT, but raly developed such infections after 2 years posttransplant. Serum IgM levels were depressed for 1 year and IgA levels for 2 years posttransplant.
