Multicentric Angiofollicular Lymphnode Hyperplasiaの1例

山村 真由美; 稲津 哲也; 木村 和弘; 佐賀 務; 中井 継彦; 宮保 進; 堂前 尚親; 細川 洋平; 服部 隆則; Masaru HUKUTA

doi:10.11406/rinketsu.28.233

A Case of Multicentric Angiofollicular Lymphnode Hyperplasia

Mayumi YAMAMURA, Tetsuya INAZU, Kazuhiro KIMURA, Tsutomu SAGA, Tsuguhiko NAKAI, Susumu MIYABO, Naotika DOMAE, Yohei HOSOKAWA, Takanori HATTORI, Masaru HUKUTA

Author information

Mayumi YAMAMURA
The Third Department of Internal Medicine, Fukui Medical School
Tetsuya INAZU
The Third Department of Internal Medicine, Fukui Medical School
Kazuhiro KIMURA
The Third Department of Internal Medicine, Fukui Medical School
Tsutomu SAGA
The Third Department of Internal Medicine, Fukui Medical School
Tsuguhiko NAKAI
The Third Department of Internal Medicine, Fukui Medical School
Susumu MIYABO
The Third Department of Internal Medicine, Fukui Medical School
Naotika DOMAE
The First Department of Internal Medicine, Fukui Medical School
Yohei HOSOKAWA
Department of the Second Pathology, Fukui Medical School
Takanori HATTORI
Department of the Second Pathology, Fukui Medical School
Masaru HUKUTA
Department of the Second Pathology, Fukui Medical School

Keywords: Castleman's disease, angiofollicular lymphnode hyperplasia, multicentric lymphadenopathy, VP therapy

JOURNAL RESTRICTED ACCESS

1987 Volume 28 Issue 2 Pages 233-238

DOI https://doi.org/10.11406/rinketsu.28.233

Details

Abstract

A Case of 48-year-old female with multicentric angiofollicular lymphnode hyperplasia (MAFH) of the plasma cell type has been reported. She had systemic manifestations such as fever, fatigue, edema, effusion, multicentric lymphadenopathy, hepatosplenomegaly, anemia, thrombocytopenia, hypergammaglobulinemia and elevation of Epstein-Barr (EB) virus related antibody. Biopsy of an axillar lymphnode showed AFH of the plasma cell type. Clinical abnormalities showed an excellent response to vincristine-prednisolone (VP) combination chemotherapy. Although the etiology is unknown, the present case was presumed to be infectious or inflammatory in nature, possibly EB virus. The VP therapy is worth trying for MAFH with systemic manifestations.

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