1987 Volume 28 Issue 2 Pages 254-260
A case of hairy cell leukemia (HCL) with 14q+ chromosomal abnormality was reported. A 62-year-old man with leukocytosis with splenomegaly showed the presence of hairy cells in peripheral blood. The neoplastic cells showed hairy appearance under phase contrast microscopy. Acid phosphatase activity was positive with diffuse appearance and α-tartrate resistant acid phosphatase activity was also observed. Peroxidase and α-naphtyl butylate esterase activity and phagocytic activities for carbon black and sensitized erythrocytes were not found in these cells. Ribosome lamella complex was negative by electron microscopy. Immunological analysis of neoplastic cells showed FcγR+, SIg+, OKIal+, B1+ but negative for T cell markers. High resolution G banding analysis showed the translocation between chromosomes 14 and 22 with breakpoints at bands p32.3 and q11.2 and a interstitial deletion of chromosome 1.
This is the first reported case of B-cell HCL revealed chromosomal abnormalites of 14q+ and Philadelphia chromosome like marker. We discuss these findings in related with cellular origin and disease entitiy of HCL.
