Abstract
A 10-year old female of hyperthyroidism developed aplastic anemia during methimazole therapy. In order to determine the mechanisms of pancytopenia, we examined the effects of patient's serum, drug and or peripheral blood mononuclear cells (MNC) on hemopoietic progenitor growth.
Numbers of hemopoietic progenitors including CFU-Mix from patient's bone marrow were significantly reduced. Colony formation of various hemopoietic progenitors from allogeneic and autologous recovered marrow was significantly inhibited by the addition of patient's acute serum. Patient's recovered serum failed to inhibit the colony growth of both bone marrow cells. These findings suggest an immunological mechanism for pancytopenia in our patient.
