1988 Volume 29 Issue 11 Pages 2011-2017
We performed blood coagulation studies in 50 patients within a week before onset of disseminated intravascular coagulation (DIC).
Since two peaks were observed for the onset, it was suspected that DIC was composed of acute and chronic types. The DIC score before onset was 4.9±1.2 in the non-leukemic group and 2.4±0.8 in the leukemic group.
Prekallikrein activity, FDP, fibrinogen and platelet number were frequently abnormal, but PT and antithrombin III weré slightly abnormal in the non-leukemic group.
Although the incidence of abnormal finding was lower in the leukemia group than in the non-leukemia group, the data on the leukemia group were similar to those on the non-leukemic group and elevated D-dimer level and decreased platelet count were particularly frequent in the leukemic group. The incidence of abnormal data in all patients was 44±14%.
Abnormalities of blood coagulation were observed within a week before the onset of DIC, and prekallikrein activity, platelet number, FDP and D-dimer might be useful for diagnosis of Pre-DIC state.
