1988 Volume 29 Issue 11 Pages 2141-2144
A 25-year-old female, who had often suffered from excessive menstruation since 11 years old, was admitted to our hospital for the control of hemostatic state at her delivery. She was born of a consanguineous marriage and diagnosed to have congenital factor VII deficiency at 24 years old. On admission, she was normal in physical examination and the prothrombin time was prolonged due to the decrease of factor VII activity reaching to 3.2%. Application of heat-treated factor VII concentrates (Immuno, Austria) was tried for hemostasis at her delivery. Two thousand units of these factor VII concentrates were given to the patient about 1 hour before her delivery. Her factor VII activity level elevated rapidly to 107.6% during the first 30 min, then decreased gradually and maintained above 20% for 6 hours. During this time, she delivered a male baby without excessive bleeding. His factor VII activity was 17.5%. Any complications were not found in the use of these factor VII concentrates.
The supplemental administration of the heat-treated factor VII concentrates was thought to be safely effective for hemostasis at delivery, especially in such a factor VII deficient patient suffering from a severe hemorrhage tendency.
