1988 Volume 29 Issue 11 Pages 2152-2157
A 34 year-old male was admitted on Dec, 27, 1985, due to an apparent fever. The white blood cell count was 15,400/μl with a differential count of 61% blasts. The red blood cell count was 251×104/μl. The Hb was 8.3g/dl. The platelet count was 2.4×104/μl. Bone marrow aspiration revealed hypercellularity with 85.2% blasts. The blasts were positive for peroxidase, naphthol ASD chloroacetate, and alpha naphthyl butyrate esterase. Acute myelomonocytic leukemia (M4) was diagnosed. The patient entered into complete remission under BHAC-DMP therapy. The patient's father, aged 65, who had been operated upon for gastric cancer 5 years ago, matched the patient's HLA. The fathers' hematological data and marrow progenitor cells were within normal limits except moderate decreased CFU-GM. Although the patient was in a relapsed state from May, 1986, bone marrow transplantation was performed on June, 9, 1986. After high dose cyclophosphamide administration (60mg/kg×2days) and TBI (3GY×4days), the patient received 3.4×108/kg nucleated marrow cells. The white blood cell count recoverd to 1,000/μl on day 35. Marrow engraftment was detected by a change of blood type (O→A). The patient remained in complete remission for 23 months after the BMT.
Our findings suggested that the recovery of the granulocyte count may in fact be slower in elderly donors.
