Abstract
We report here a childhood MDS with inv(11)(p15q23). A 7-year-old boy with mild thrombocytopenia had been observed without medication since May 1983. In November 1984 he became pancytopenic. A diagnosis of aplastic anemia was made according to his markedly hypocellular bone marrow. He was treated with prednisolone and oxymetholone with good response. In June 1986, myeloblasts with Auer's rods were seen in peripheral blood; bone marrow was hypercellular with 6.2% of myeloblasts. A diagnosis of RAEB-T was made. In September 1986, WBC count was increased to 75,500/μl, but its majority were mature neutrophils, and NAP score was 0 (0%). A diagnosis of CMMoL (FAB) was made and he was treated with low dose aclarubicin and cytarabin, but died of intracranial bleeding on October 9, 1986.
Nine cases have been reported so far on non-lymphocytic leukemia with chromosome abnormalities involving band 11p15. Three of them and present case showed blood pictures similar to CML. It is suggested that leukemia with 11p15 break is a subgroup which shows CML like blood picture.
