Abstract
A 44-year-old male who had been diagnosed as primary myelofibrosis in 1981 was admitted on March, 1985 because of splenomegaly, thrombocytopenia and leucocytosis with 28% blast cells. In cytochemical findings, a large number of blast cells were peroxidase-negative, PAS-negative, α-naphthyl acetate esterase positive, and acid phosphatase positive. These blasts were also positive for monoclonal antiplatelet glycoprotein IIb/IIIa complex antibody. A few blasts were myeloperoxidase positive. Immune electron microscopic examination also revealed that platelet peroxidase reaction was positive in many blast cells and myeloperoxidase reaction was positive in a few blast cells. Chromosome analysis of the peripheral blood showed t(3q-, cq+). From these findings he was diagnosed as having primary myelofibrosis terminating in magakaryoblastic crisis. He did not respond to a chemotherapy and expired in February 26th in 1986. Autopsy was not done.
