1988 Volume 29 Issue 5 Pages 676-681
Ten children with aplastic anemia (9 severe; 1 moderate) were treated with antilymphocyte globulin (ALG; Ahlbulin, Green Cross Co., Osaka, Japan). Four of them received the combination of ALG and high dose methylprednisolone (HDMP). Seven children were administered with danazol concurrently for at least 3 months. A complete hematological response was noted in 4 children. Three died, two of whom died of infection and the other died of intracranial bleeding. Seven out of the ten children are still alived and the duration vary from 3 to 48 months following the start of the ALG therapy. Complications of the ALG therapy were few. This data indicated that ALG is effective in improving hematopoiesis in some children with aplastic anemia.
