1988 Volume 29 Issue 5 Pages 718-722
Two cases of drug-induced MDS with monosomy 7 were reported. The first case was a 68-year-old woman, who had received alkylating agents such as melphalan and cyclophosphamide after hysterectomy for uterine cancer. Five years after hysterectomy, she complained of palpitation, and pancytopenia developed. The bone marrow was normocellular with 11.6% myeloblasts and decreased megakaryocytes and erythroblasts. The patient was diagnosed to have refractory anemia with excess of blasts (RAEB). Chromosomal analysis of the bone marrow cells revealed monosomy 7. She is alive eight months after diagnosis. The second case was a 60-year-old male. He had received chemotherapy with melphalan, vincristine and prednisolone for five and a half years against multiple myeloma. Six years after the start of chemotherapy, he had pyrexia and anemia. The bone marrow was normocellular with 11.2% myeloblasts and increased megakaryocytes. The patient was diagnosed to have RAEB. Chromosomal analysis of the bone marrow cells revealed four types of abnormal karyotypes each with monosomy 7. He died of severe anemia four months after diagnosis of RAEB.
