Studies of Five Cases with Lowered Eosinophil Peroxidase Activity Found Using an Automated Hematology Analyzer (Technicon H6000 System)

Abstract

The Technicon H6000 Hematology System simultaneously determines blood cell and leukocyte differential counts automatically based on the method of cytochemistry and cell size measurements. A part of the information provided using this instrument is the histogram of peroxidase staining intensity in leukocytes compared with cell size of the leukocyte called “The Leukocyte Peroxidase Distribution Picture”.
Approximately 340,000 blood sample-days representing the hematological examinations at the Central Clinical Laboratory, Osaka Medical College Hospital, were examined for the individual leukocyte peroxidase distribution pictures of these samples for the 42 month period from January 1984 to June 1987. From the results of this examination, five cases with lowered eosinophil peroxidase activity were found.
It is anticipated that further cases with lowered eosinophil peroxidase activity will be found as the Technicon H6000 Hematology System is more widely used in routine examinations, in comparison with the other leukocyte differential methods.