1988 Volume 29 Issue 5 Pages 769-775
A case of severe aplastic anemia assosiated with cyclic thrombocytopenia who has been obtained complete remission by intravenous high dose gammaglobulin therapy was reported. This ten-month-old girl with tentative diagnosis of pure red cell aplasia was referred to our university hospital. Laboratory examination revealed hypocellular marrow, negative Coombs' test and normal serum immunoglobulin levels. Inspite of daily prednisolone therapy, anemia was not improved, but transient reticulocytosis was observed during an administration of gammaglobulin (120mg/kg) for complications of interstitial pneumonia. High dose gammaglobulin therapy (400mg/kg×5days) resulted a complete relief of anemia and cyclic thrombocytopenia and she has remained in a state of complete remission for more than a year.
Mechanism of the response was uncertain, high dose gammaglobulin should be considered one of the valuable treatments for aplastic anemia.