Abstract
We report a case of multiple myeloma (MM) IgG (κ) treated with cyclophosphamide (CPA) in which bladder cancer (transitional cell carcinoma, grade III) appeared in the course. The patient was a 73-year-old male who had been diagnosed as having MM in 1973, and therapy with melphalan and later with CPA was started in 1977. In 1984 hematuria was evident, however, it had been diagnosed as CPA-induced hemorrhagic cystitis. In 1986 he admitted to the Tokyo Medical College Hospital and was treated with modified VAD therapy, since the disease progressed. During the therapy, bladder cancer was found, and he was treated with intra-bladder administration of adriamycin. However, he died of renal failure in June, 1987. All of the reported MM patients treated with CPA and bladder cancer were male, and the total doses of CPA were more than 100 grams in most of the cases.
