1988 Volume 29 Issue 9 Pages 1488-1492
The patient was a 23-year-old female who had been followed as Ph1-positive chronic myeloid leukemia (CML) in the chronic phase over 12 years. The patient manifested hemorrhagic tendency and was diagnosed as having blastic crisis by the hematologic examination. At this time, an increasing number of Gaucher-like cells was observed in her bone marrow. According to the electron microscopic study, these Gaucher-like cells had abundant cytoplasm containing tubular structural inclusion bodies. Chromosome analysis of the bone marrow cells at this time revealed that cells without a Ph1-chromosome were present. Surface marker analysis of the blasts revealed to be of B-lymphoid characteristics; B4 88.3%, J5 93.1% and OKIal 87.0%, though they contained myeloperoxidase positive granules by the electron microscopic examination. DNA analysis showed that the bone marrow cells in the blastic crisis had JH rearrangement, indicating the blasts had biphenotypic nature.
