Abstract
A 40-year-old man who was resected ascending colon and terminal ileum (10 cm) in Aug. 1978, with the diagnosis of Crohn's disease, was admitted to our hospital with general fatigue, paresthesia and tremor in May. 1984. A peripheral blood examination on admission revealed Hb 10.1 g/dl, RBC 234×104/mm3, MCV 131.4 fl, MCH 43.2 pg. A bone marrow specimen showed marked erythroid hyperplasia (W/E 1.44) with megaloblastic change. While serum folate level was normal, serum vitamin B12 value was low and Schilling test showed vitamin B12 disabsorption. Roentgenologic and endoscopic examinations revealed diffuse cobble stone appearances in small intestine (from anastomosis part to duodenal bulb). These examinations suggested vitamin B12 disabsorption with diffuse Crohn's disease caused megaloblastic anemia.
The patient had been treated with vitamin B12 1,000 μg/day injection and, in Sep. 1984, he recovered from megaloblastic anemia (Hb 13.4 g/dl, RBC 440×104/mm3, MCV 90.7 fl, MCH 30.4 pg).
