輸血後非A非B型肝炎に対しα-IFNと大量SNMC投与後同種骨髄移植が可能となったAMLの2例

橋野 聡; 今村 雅寛; 小林 一; 田中 雅則; 福原 敬; 藤本 比沙雄; 狩野 吉康; 吉田 純一; 桜田 恵右; 松嶋 喬; 宮崎 保; 川村 憲一; 笠井 正晴; 川村 詔導; 前川 勲

doi:10.11406/rinketsu.30.2029

Allogeneic Bone Marrow Transplantation After the Treatment of α-IFN and High-dose SNMC in Two Cases of Acute Myeloblastic Leukemia with Post-transfusional Non-A, Non-B Hepatitis

Satoshi HASHINO, Masahiro IMAMURA, Hajime KOBAYASHI, Masanori TANAKA, Takashi FUKUHARA, Hisao FUJIMOTO, Yoshiyasu KARINO, Junichi YOSHIDA, Keisuke SAKURADA, Takashi MATSUSHIMA, Tamotsu MIYAZAKI, Kenichi KAWAMURA, Masaharu KASAI, Tsugumichi KAWAMURA, Isao MAEKAWA

Author information

Satoshi HASHINO
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Masahiro IMAMURA
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Hajime KOBAYASHI
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Masanori TANAKA
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Takashi FUKUHARA
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Hisao FUJIMOTO
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Yoshiyasu KARINO
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Junichi YOSHIDA
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Keisuke SAKURADA
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Takashi MATSUSHIMA
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Tamotsu MIYAZAKI
The Third Department of Internal Medicine, Hokkaido University School of Medicine
Kenichi KAWAMURA
Department of Internal Medicine, Sapporo Hokuyu Hospital
Masaharu KASAI
Department of Internal Medicine, Sapporo Hokuyu Hospital
Tsugumichi KAWAMURA
Department of Internal Medicine, Asahikawa Municipal Hospital
Isao MAEKAWA
Department of Internal Medicine, Asahikawa Municipal Hospital

Keywords: bone marrow transplantation, non-A, non-B hepatitis, interferon

JOURNAL RESTRICTED ACCESS

1989 Volume 30 Issue 11 Pages 2029-2034

DOI https://doi.org/10.11406/rinketsu.30.2029

Details

Abstract

Two patients of acute myeloblastic leukemia (M2) with post-transfusional hepatitis (non-A, non-B) were treated with α-IFN and high-dose SNMC before allogeneic bone marrow transplantation. Bone marrow transplantation from HLA identical and MLR negative sibling donor was carried out when their hepatic functions were almost normalized. In the early phase after bone marrow transplantation, the hepatic function in both two cases has been stable, thus indicating that this treatment should be tried for reducing hepatic dysfunction and for safety bone marrow transplantation.

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