Abstract
We describe a patient with CML who developed hypercalcemia in his course of blast crisis.
A 25-years-old man was diagnosed as CML with priapism in April 1985, and controlled with BHAC-DVP, VMP, busufan therapy. In Decenber 1987, he readmited to our hospital with abdominal pain. Investgations at that time showed: white blood cell count 11600/μl (blast cells 9%); hemoglobin 8.4 g/μl; platlets 19.0×104/μl; serum calcium 13.2 mg/dl; BUN 44 mg/dl; creatinine 2.7 mg/dl.
Treatment with predonine, 6-MP and vincristine was begun. But serum calcium level rose gradually up to 16.5 mg/dl. So we tried middle dose Ara-c therapy, serum calcium decreased to 6.8 mg/dl.
At once he was in a chronic phase, but he relapsed and died of heart failure.
Necropsy showed extensive leukemic blast-cell infiltration of the bone marrow, liver, spleen, lung, and kidney.
The cause of hypercalcemia in our case was suspected of local osteolitic hypercalcemia, because multiple bone destruction was found.
