自家骨髄移植後の好中球減少に対するrecombinant human granulocyte colony-stimulating factor (rG·CSF注)の臨床評価

高橋 聡; 浅野 茂隆; 正岡 徹; 高久 史麿; 新津 洋司郎; 渋谷 温; 斎藤 博; 関根 勇夫; 三比 和美; 花田 良二; 大藤 正雄; 伊藤 尹敦; 大平 睦郎; 麦島 秀雄; 児玉 文雄; 関 茂樹; 白川 茂; 小西 省三郎

doi:10.11406/rinketsu.32.221

Clinical Evalution of Recombinant Human Granulocyte Colony-stimulating Factor (rhG-CSF) in Autologous Bone Marrow Transplantation

Satoshi TAKAHASHI, Shigetaka ASANO, Tohru MASAOKA, Fumimaro TAKAKU, Youjiro NIITSU, Atsushi SHIBUYA, Hiroshi SAITO, Isao SEKINE, Kazumi SANPI, Ryoji HANADA, Masao OHTO, Tadaatsu ITO, Mutsuro OHIRA, Hideo MUGISHIMA, Fumio KODAMA, Shigeki SEKI, Shigeru SHIRAKAWA, Shozaburo KONISHI

Author information

Satoshi TAKAHASHI
Department of Hematology-Oncology, Institute of Medical Science, University of Tokyo
Shigetaka ASANO
Department of Hematology-Oncology, Institute of Medical Science, University of Tokyo
Tohru MASAOKA
The 5th Department of Internal Medicine, The Center for Adult Disease
Fumimaro TAKAKU
Department of Hematology-Oncology, Institute of Medical Science, University of Tokyo
Youjiro NIITSU
The 4th Department of Internal Medicine, Sapporo Medical College
Atsushi SHIBUYA
Department of Pediatrics, Saitama Medical School
Hiroshi SAITO
Department of Urology, Saitama Medical Center
Isao SEKINE
Department of Pediatrics, National Defense Medical School
Kazumi SANPI
Department of Hematology, Saitama Cancer Center
Ryoji HANADA
Devision of Hematology/Oncology, Saitama Children's Medical Center
Masao OHTO
The 1st Department of Internal Medicine, Chiba University
Tadaatsu ITO
Department of Pediatrics, Teikyo University School of Medicine
Mutsuro OHIRA
Department of Pediatrics, National Cancer Center
Hideo MUGISHIMA
Department of Pediatrics, Nihon University School of Medicine
Fumio KODAMA
The 4th Department of Internal Medicine, Kanagawa Prefectural Cancer Center
Shigeki SEKI
Department of Internal Medicine, Saku General Hospital
Shigeru SHIRAKAWA
The 2nd Department of Internal Medicine, Mie University
Shozaburo KONISHI
The 2nd Department of Internal Medicine, Osaka Prefectural Pediatrics Healthy Center

Keywords: RhG-CSF, bone marrow transplantation, neutropenia, infection

JOURNAL RESTRICTED ACCESS

1991 Volume 32 Issue 3 Pages 221-226

DOI https://doi.org/10.11406/rinketsu.32.221

Details

Abstract

We administered recombinant human granulocyte colony-stimulating factor (rhG-CSF) at 5 μg/kg/day by intravenous drip infusion for 21 consecutive days in autologous bone marrow transplanted patients. The period of posttransplant neutropenia was markedly shortend by the rhG-CSF treatment; mean days required for neutrophil recovery (>500/mm³) of 14.3 days in the rhG-CSF group (n=21) versus 27.8 days in the historical control group (n=11). More importantly, the numbers of febrile days between day 15 and day 28 were found to be fewer in the rG-CSF group than in control group. These effects were obtained without delay in the recovery of other blood cell series and without any side effect. We conclude that the posttransplant use of the rhG-CSF is beneficial for prevention and treatment of infectious complications after autologous bone marrow transplantation.

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