1994 Volume 35 Issue 6 Pages 552-556
A 51-year-old man had suffered from massive pleural effusion due to invasion of malignant cells. The analysis of bone marrow asppiration showed the proliferation of myeloperoxidase-positive blasts. The surface marker analysis of the blasts revealed the positivities for CD7 and CD19 as well as CD13, CD33 and CD34, while the karyotypes of 20 cells were normal. Therefore, CD7 positive AML was diagnosed. The patient was treated with araC and daunorubicin as a remission induction therapy. Peripheral blood stem cells were harvested by leukapheresis after first and second consolidation therapies. Then, 3×104 cells/kg of CFU-GM were infused. Complete remission has been maintained for 8 months after autologous blood stem cell transplantatin. Pleural involvement as an initial manifestation is rare in AML. Extramedullary growth of AML cells may be related to their immaturity, indicated by the expression of the cell surface antigens.
