高齢母親（75歳）の凍結保存骨髄細胞を移植した急性リンパ性白血病の1例

鵜池 直邦; 末廣 陽子; 高比良 宏之; 島田 豊; 永利 義久; 生野 茅子; 岡村 純; 田坂 英子; 宮村 友也; 石倉 英樹; 高月 浩; 山下 早百合; 梅村 創; 西村 純二; 小鶴 三男

doi:10.11406/rinketsu.35.801

Bone Marrow Transplantation for a Patient with ALL from her 75-year-old Mother Using Cryopreserved Bone Marrow Cells

Naokuni UIKE, Youko SUEHIRO, Hiroyuki TAKAHIRA, Yutaka SHIMADA, Yoshihisa NAGATOSHI, Yoshiko IKUNO, Jun OKAMURA, Hideko TASAKA, Tomoya MIYAMURA, Hideki ISHIKURA, Hiroshi TAKATSUKI, Sayuri YAMASHITA, Tsukuru UMEMURA, Junji NISHIMURA, Mitsuo KOZURU

Author information

Naokuni UIKE
Department of Hematology, National Kyushu Cancer Center Hospital
Youko SUEHIRO
Department of Hematology, National Kyushu Cancer Center Hospital
Hiroyuki TAKAHIRA
Department of Hematology, National Kyushu Cancer Center Hospital
Yutaka SHIMADA
Department of Pediatrics, National Kyushu Cancer Center Hospital
Yoshihisa NAGATOSHI
Department of Pediatrics, National Kyushu Cancer Center Hospital
Yoshiko IKUNO
Department of Pediatrics, National Kyushu Cancer Center Hospital
Jun OKAMURA
Department of Pediatrics, National Kyushu Cancer Center Hospital
Hideko TASAKA
Department of Pediatrics, National Kyushu Cancer Center Hospital
Tomoya MIYAMURA
Third Department of Internal Medicine, Kyushu University School of Medicine
Hideki ISHIKURA
Third Department of Internal Medicine, Kyushu University School of Medicine
Hiroshi TAKATSUKI
Third Department of Internal Medicine, Kyushu University School of Medicine
Sayuri YAMASHITA
Third Department of Internal Medicine, Kyushu University School of Medicine
Tsukuru UMEMURA
Department of Medical Technology, School of Health Sciences, Kyushu University
Junji NISHIMURA
Third Department of Internal Medicine, Kyushu University School of Medicine
Mitsuo KOZURU
Department of Hematology, National Kyushu Cancer Center Hospital

Keywords: bone marrow transplantation, ALL, 75-year-old donor, cryopreservation

JOURNAL RESTRICTED ACCESS

1994 Volume 35 Issue 8 Pages 801-803

DOI https://doi.org/10.11406/rinketsu.35.801

Details

Abstract

We report a 42-year-old woman with acute lymphoblastic leukemia who received allogeneic bone marrow transplantation (BMT) in the first remission from her 75-year-old, HLA-identical, MLC-nonreactive mother. Considering the difficulty to obtain a sufficient number of bone marrow cells from such an old donor, we harvested the cells (2.31×10⁸/kg) on day -37 and cryopreserved them until use. BMT was performed on June 3rd, 1993 after conditioning regimen with total body irradiation, high-dose AraC and cyclophosphamide. Graft-versus-host disease (GVHD) prophylaxisis was attempted by cyclosporin A and short-term methtrexate. Her hematopoietic recovery was favorable with no signs and symptoms of GVHD as far as day 218.

Corresponding author

Register with J-STAGE for free!