Hematological Stability under Ubenimex Monotherapy in a Patient with Acute Myelogenous Leukemia Developing Marrow Karyotypic Changes during the Course

Abstract

We encountered a 71-year-old female with acute myelogenous leukemia (AML, Ml), who maintained a steady hematological state for 22 months under ubenimex monotherapy. At the first medical examination in our hospital, the marrow cellularity was approximately 40% containing leukemic myeloblasts of 41.4% in the total nucleated cells, and the marrow cytogenetic studty revealed 47, XX, +8 in 13 of 20 cells analyzed. Nineteen months later, the bone marrow showed definite hypoplasia with leukemic blasts of 39.8% and chromosome finding of 46, XX, ins (10;?)(q11;?) in all cells analyzed. During the course, the patient has been doing well without transfusin of red blood cells or platelets.