PUVA Therapy for Cutaneous Acute Graft-Versus-Host Disease

—A Case Report—

Abstract

We performed 8-methoxypsolaren and ultraviolet A (PUVA) therapy as a second line treatment for stage +++ cutaneous acute graft-versus-host disease (GVHD) in a 10-year-old girl who had undergone unrelated bone marrow transplantation. Although prednisolone as first line therapy was not effective, the cutaneous lesion began to improve after several times of PUVA treatment and completely disappeared following 11 times of irradiation without additive systemic immunosuppressive therapy. PUVA therapy was considered as a useful treatment for cutaneous acute GVHD.