Hydroxyurea投与中に両側外果部潰瘍を合併した慢性骨髄性白血病の1例

増岡 秀一; 小林 正之; 海渡 健; 吉田 真弓; 関田 徹; 佐伯 明子; 西脇 嘉一; 島田 貴; 落合 成正; 大坪 寛子; 小笠原 洋治; 酒井 紀

doi:10.11406/rinketsu.36.156

Bilateral Ankle Ulcers Associated with Hydroxyurea Therapy for Chronic Myelogenous Leukemia

Hidekazu MASUOKA, Masayuki KOBAYASHI, Ken KAITO, Mayumi YOSHIDA, Tohru SEKITA, Akiko SAEKI, Kaichi NISHIWAKI, Takaki SHIMADA, Shigemasa OCHIAI, Hiroko OOTSUBO, Youji OGASAWARA, Osamu SAKAI

Author information

Hidekazu MASUOKA
Second deparment of Internal Medicine, The Jikei University School of Medicin
Masayuki KOBAYASHI
Department of Laboratory Medicine, The Jikei University School of Medicine
Ken KAITO
Second deparment of Internal Medicine, The Jikei University School of Medicin
Mayumi YOSHIDA
Second deparment of Internal Medicine, The Jikei University School of Medicin
Tohru SEKITA
Second deparment of Internal Medicine, The Jikei University School of Medicin
Akiko SAEKI
Second deparment of Internal Medicine, The Jikei University School of Medicin
Kaichi NISHIWAKI
Second deparment of Internal Medicine, The Jikei University School of Medicin
Takaki SHIMADA
Second deparment of Internal Medicine, The Jikei University School of Medicin
Shigemasa OCHIAI
Second deparment of Internal Medicine, The Jikei University School of Medicin
Hiroko OOTSUBO
Second deparment of Internal Medicine, The Jikei University School of Medicin
Youji OGASAWARA
Second deparment of Internal Medicine, The Jikei University School of Medicin
Osamu SAKAI
Second deparment of Internal Medicine, The Jikei University School of Medicin

Keywords: chronic myelogenous leukemia, hydroxyurea, skin ulcer

JOURNAL RESTRICTED ACCESS

1995 Volume 36 Issue 2 Pages 156-158

DOI https://doi.org/10.11406/rinketsu.36.156

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Abstract

Bilateral ankle skin ulcers developed in a 61-year-old man in the chronic phase of chronic myelogenous leukemia receiving hydroxyurea therapy. The circulating immune complex (anti-C_3d antibody) was high in this case, but vasculitis was not observed in the pathological findings of biopsied skin materials. This association has been reported in patients who had chronic myelogenous leukemia or other myeloproliferative disorders and were treated with hydroxyurea. It is likely that skin ulcers are caused by hydroxyurea.

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