経過中血小板増加を伴う骨髄異形成症候群を発症した多発性骨髄腫

中山 道弘; 小林 幸夫; 大島 康雄; 植村 直樹; 新道 英一; 田近 賢二; 柳沢 孝次; 高橋 聡; 入江 誠治; 東條 有伸; 谷 憲三朗; 小澤 敬也; 浅野 茂隆

doi:10.11406/rinketsu.36.703

Multiple Myeloma Developing Myelodysplastic Syndrome with Thrombocytosis

Michihiro NAKAYAMA, Yukio KOBAYASHI, Yasuo OSHIMA, Naoki UEMURA, Eiichi SHINDO, Kenzi TAJIKA, Koji YANAGISAWA, Satoshi TAKAHASHI, Seiji IRIE, Arinobu TOJO, Kenzaburo TANI, Keiya OZAWA, Shigetaka ASANO

Author information

Michihiro NAKAYAMA
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
The First Department of Internal Medicine, Toho University
Yukio KOBAYASHI
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Yasuo OSHIMA
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Naoki UEMURA
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Eiichi SHINDO
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Kenzi TAJIKA
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Koji YANAGISAWA
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Satoshi TAKAHASHI
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Seiji IRIE
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Arinobu TOJO
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Kenzaburo TANI
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Keiya OZAWA
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo
Shigetaka ASANO
Department of Hematology/Oncology Institute of Medical Science, University of Tokyo

Keywords: Multiple, Myeloma, MDS, Thrombocytosis, 5q^-

JOURNAL RESTRICTED ACCESS

1995 Volume 36 Issue 7 Pages 703-706

DOI https://doi.org/10.11406/rinketsu.36.703

Details

Abstract

A 64-year-old woman with multiple myeloma, IgGλ type Durie-Salmon Stage II, was admitted because of gradually developing anemia and increased blasts with abnormal karyotype in her bone marrow after 10 years of treatment. The chromosomal analysis showed 44, XX, del(5q), del(7q), -9, add(12p), -21, typical of secondary MDS due to the cumulative alkylating agents. Thrombocytosis concomitantly occurred with emergence of chromosomal abnormality, but the serum interleukin 6 level was not elevated, which suggested that it was related to development of secondary MDS.

Corresponding author

Register with J-STAGE for free!