A Combination Chemotherapy with Cytarabine Ocfosfate, Low Dose Etoposide, and G-CSF for the Treatment of High Risk MDS (RAEB, RAEBt) —A Pilot Study—

Abstract

We evaluated a combination chemotherapy with cytarabine ocfosfate (SPAC), low dose etoposide and G-CSF for the treatment of high-risk MDS (RAEB, RAEBt). Seven patients with high-risk MDS were treated with a daily combination, 200mg/day SPAC po, 50mg/day etoposide po and 75μg/day G-CSF sc. One patient achieved complete response, 2 achieved good response and one patient minor response. Although all of the patients developed severe marrow hypoplasia after chemotherapy, the nonhematologic adverse effects were mild enough to be tolerated. This combination chemotherapy should be useful in the clinical management of patients with high-risk MDS.