メシル酸イマチニブによる急激な好塩基球減少を契機に全身性紅斑を呈した慢性骨髄性白血病

杉藤 素子; 塚田 順一; 東 丈裕; 太田 貴徳; 松浦 愛; 窪田 歩; 溝部 貴光; 毛利 文彦; 森本 浩章; 田中 良哉

doi:10.11406/rinketsu.46.1226

Generalized erythema triggered by a rapid decrease of basophils in chronic myeloid leukemia treated with imatinib

Motoko SUGITO, Junichi TSUKADA, Takehiro HIGASHI, Takanori OHTA, Ai MATSUURA, Ayumu KUBOTA, Takamitsu MIZOBE, Fumihiko MOURI, Hiroaki MORIMOTO, Yoshiya TANAKA

Author information

Motoko SUGITO
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Junichi TSUKADA
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Takehiro HIGASHI
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Takanori OHTA
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Ai MATSUURA
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Ayumu KUBOTA
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Takamitsu MIZOBE
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Fumihiko MOURI
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Hiroaki MORIMOTO
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Yoshiya TANAKA
First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine

Keywords: Chronic myeloid leukemia, Imatinib, Skin erythema, Basophilia

JOURNAL RESTRICTED ACCESS

2005 Volume 46 Issue 11 Pages 1226-1228

DOI https://doi.org/10.11406/rinketsu.46.1226

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Abstract

A 57-year-old woman with chronic myeloid leukemia showing severe basophilia (WBC 17.1×10⁹/L, basophils 23%) was treated with 400mg imatinib in June 2003. A high basophil count (WBC 10.6×10⁹/L, basophils 31%) was still observed after 1 week of therapy. After 9 days of therapy, she developed generalized pruritic skin erythema, chills and high fever. After terminating imatinib treatment, prednisolone therapy was initiated. The rash quickly disappeared. Four days after withdrawal of imatinib, leukocyte count was 13.0×10⁹/L with 3% of basophils, suggesting the possibility that rapid decrease in basophils following imatinib therapy may induce severe cutaneous reactions.

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