リンパ腫細胞由来のインターロイキン-5が好酸球増多を来したと考えられる末梢性T細胞性リンパ腫

松永 卓也; 佐藤 勉; 井山 諭; 田中 信悟; 村瀬 和幸; 佐藤 康史; 小船 雅義; 瀧本 理修; 加藤 淳二; 黒田 裕行; 新津 洋司郎

doi:10.11406/rinketsu.47.1457

Case Reports

Peripheral T-cell lymphoma presenting with eosinophilia due to Interleukin-5 produced by lymphoma cells

Takuya MATSUNAGA, Tsutomu SATO, Satoshi IYAMA, Shingo TANAKA, Kazuyuki MURASE, Yasushi SATO, Masayoshi KOBUNE, Rishu TAKIMOTO, Junji KATO, Hiroyuki KURODA, Yoshiro NIITSU

Author information

Takuya MATSUNAGA
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Tsutomu SATO
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Satoshi IYAMA
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Shingo TANAKA
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Kazuyuki MURASE
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Yasushi SATO
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Masayoshi KOBUNE
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Rishu TAKIMOTO
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Junji KATO
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
Hiroyuki KURODA
Division of Gastroenterology, Chitose City Hospital
Yoshiro NIITSU
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine

Keywords: Peripheral T-cell lymphoma, Eosinophilia, Interleukin-5

JOURNAL RESTRICTED ACCESS

2006 Volume 47 Issue 11 Pages 1457-1462

DOI https://doi.org/10.11406/rinketsu.47.1457

Details

Abstract

A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

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