Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
Case Reports
Monomorphic post-transplant T-lymphoproliferative disorder after autologous stem cell transplantation for multiple myeloma
Tetsuya ISHIKAWAHiroaki SHIMIZUToshifumi TAKEIHiroko KOYAHirono IRIUCHISHIMATakumi HOSIHOJunko HIRATOMasaru KOJIMAHiroshi HANDAYoshihisa NOJIMAHirokazu MURAKAMI
Author information
JOURNAL RESTRICTED ACCESS

2016 Volume 57 Issue 1 Pages 36-40

Details
Abstract

We report a rare case of T cell type monomorphic post-transplant lymphoproliferative disorders (PTLD) after autologous stem cell transplantation. A 53-year-old man with multiple myeloma received autologous stem cell transplantation and achieved a very good partial response. Nine months later, he developed a high fever and consciousness disturbance, and had multiple swollen lymph nodes and a high titer of Epstein-Barr (EB) virus DNA in his peripheral blood. Neither CT nor MRI of the brain revealed any abnormalities. Cerebrospinal fluid contained no malignant cells, but the EB virus DNA titer was high. Lymph node biopsy revealed T cell type monomorphic PTLD. Soon after high-dose treatment with methotrexate and cytosine arabinoside, the high fever and consciousness disturbance subsided, and the lymph node swelling and EB virus DNA disappeared. Given the efficacy of chemotherapy in this case, we concluded that the consciousness disturbance had been induced by central nervous system involvement of monomorphic PTLD.

Content from these authors
© 2016 The Japanese Society of Hematology
Previous article Next article
feedback
Top